Partitioned Domino® servers and IP addresses
When you set up an IBM® Domino® partitioned server, it is usually best to assign a separate IP address to each partition and use a separate NIC for each. Using a separate NIC for each address can make the computer's I/O much faster.
Domino® is designed to listen for TCP/IP connections on all NICs in a computer system. If more than one partition is hosting the same service (NRPC, SMTP, POP3, IMAP, LDAP, or HTTP), fine-tune which partitions listen for which connections by associating each service's TCP port with a specific IP address.
As an alternative to using a separate NIC for each IP address, you can use a single NIC and still assign a separate IP address to each partition.
If you are unable to assign a separate IP address to each partition, you can use port mapping.